Horsfall, LJ;
(2005)
The clinical and economic consequences of genetic testing to prevent irinotecan-induced toxicity: evaluating a pharmacogenetic health technology.
Masters thesis , University of York.
Abstract
Objective: To develop and apply a set of criteria to current evidence to evaluate a pharmacogenetic health intervention. Design: A two-phase design using qualitative techniques to develop a set of criteria appropriate for pharmacogenetic technology assessment, and application of these criteria to qualitatively and quantitatively evaluate the clinical and economic consequences a pharmacogenetic strategy to prevent irinotecan-induced toxicities. Methods: Published literature and guidelines were used to derive a set of criteria to measure the potential outcomes of a pharmacogenetic intervention. The main outcomes of clinical effectiveness and cost-effectiveness were measured using systematic review including meta-analysis and decision modelling. Results: A pharmacogenetic intervention to reduce irinotecan-induced toxicity has high potential for clinical and cost-effectiveness for the NHS and further research would be cost-effective. Conclusions: Lack of research interest and perceptions of the exceptional nature of genetics could in part be responsible for the absence of pharmacogenetic technologies from clinical practice. Clinical-effectiveness organisations need to develop appropriate guidelines using methods from health services research for appraising pharmacogenetic technologies. Patients with genetic condition Gilbert’s syndrome are at high-risk of severe toxicity to irinotecan chemotherapy and by pre-treatment pharmacogenetic screening could be beneficial both clinically and economically.
| Type: | Thesis (Masters) |
|---|---|
| Title: | The clinical and economic consequences of genetic testing to prevent irinotecan-induced toxicity: evaluating a pharmacogenetic health technology |
| Event: | University of York |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1388102 |
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