Alasaari, JS;
Lagus, M;
Ollila, HM;
Toivola, A;
Kivimäki, M;
Vahtera, J;
Kronholm, E;
... Paunio, T; + view all
(2012)
Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort.
PLoS One
, 7
(9)
, Article e45813. 10.1371/journal.pone.0045813.
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Abstract
Shift-working nurses are exposed to a stressful work environment, which puts them at an increased risk for burnout and depression. We explored the effect of environmental stress on serotonin transporter gene (SLC6A4) promoter methylation among nurses from high and low work stress environments.
| Type: | Article |
|---|---|
| Title: | Environmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0045813 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0045813 |
| Language: | English |
| Additional information: | © Alasaari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3461019 |
| Keywords: | Adolescent, Adult, Base Sequence, Burnout, Professional, CpG Islands, DNA Methylation, Depression, Female, Genotype, Humans, Molecular Sequence Data, Nurses, Occupational Diseases, Polymorphism, Genetic, Promoter Regions, Genetic, Sequence Analysis, DNA, Serotonin Plasma Membrane Transport Proteins, Work Schedule Tolerance, Young Adult |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1387339 |
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