Peters, A;
Pitcher, LA;
Sullivan, JM;
Mitsdoerffer, M;
Acton, SE;
Franz, B;
Wucherpfennig, K;
... Kuchroo, VK; + view all
(2011)
Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation.
Immunity
, 35
(6)
pp. 986-996.
10.1016/j.immuni.2011.10.015.
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Abstract
Ectopic lymphoid follicles are hallmarks of chronic autoimmune inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis, Sjögren's syndrome, and myasthenia gravis. However, the effector cells and mechanisms that induce their development are unknown. Here we showed that in experimental autoimmune encephalomyelitis (EAE), the animal model of MS, Th17 cells specifically induced ectopic lymphoid follicles in the central nervous system (CNS). Development of ectopic lymphoid follicles was partly dependent on the cytokine interleukin 17 (IL-17) and on the cell surface molecule Podoplanin (Pdp), which was expressed on Th17 cells, but not on other effector T cell subsets. Pdp was also crucial for the development of secondary lymphoid structures: Pdp-deficient mice lacked peripheral lymph nodes and had a defect in forming normal lymphoid follicles and germinal centers in spleen and lymph node remnants. Thus, Th17 cells are uniquely endowed to induce tissue inflammation, characterized by ectopic lymphoid follicles within the target organ.
| Type: | Article |
|---|---|
| Title: | Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.immuni.2011.10.015 |
| Publisher version: | https://doi.org/10.1016/j.immuni.2011.10.015 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Central Nervous System, Lymphoid Tissue, Animals, Mice, Inbred C57BL, Transgenic, Multiple Sclerosis, Encephalomyelitis, Autoimmune, Experimental, Membrane Glycoproteins, Th17 Cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1387304 |
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