Chaillon, A;
Braibant, M;
Hué, S;
Bencharif, S;
Enard, D;
Moreau, A;
Samri, A;
... Barin, F; + view all
(2012)
Human immunodeficiency virus type-1 (HIV-1) continues to evolve in presence of broadly neutralizing antibodies more than ten years after infection.
PLoS One
, 7
(8)
, Article e44163. 10.1371/journal.pone.0044163.
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Abstract
The evolution of HIV-1 and its immune escape to autologous neutralizing antibodies (Nabs) during the acute/early phases of infection have been analyzed in depth in many studies. In contrast, little is known about neither the long-term evolution of the virus in patients who developed broadly Nabs (bNabs) or the mechanism of escape in presence of these bNabs.
| Type: | Article |
|---|---|
| Title: | Human immunodeficiency virus type-1 (HIV-1) continues to evolve in presence of broadly neutralizing antibodies more than ten years after infection. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0044163 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0044163 |
| Language: | English |
| Additional information: | © Chaillon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3431314 |
| Keywords: | Amino Acid Sequence, Analysis of Variance, Antibodies, Neutralizing, Bayes Theorem, Evolution, Molecular, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Likelihood Functions, Markov Chains, Models, Genetic, Monte Carlo Method, Phylogeny, Selection, Genetic, Sensitivity and Specificity, Sequence Analysis, DNA, Survivors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1386323 |
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