Bloom, CI;
Graham, CM;
Berry, MP;
Wilkinson, KA;
Oni, T;
Rozakeas, F;
Xu, Z;
... O'Garra, A; + view all
(2012)
Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy.
PLoS One
, 7
(10)
, Article e46191. 10.1371/journal.pone.0046191.
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Abstract
Globally there are approximately 9 million new active tuberculosis cases and 1.4 million deaths annually. Effective antituberculosis treatment monitoring is difficult as there are no existing biomarkers of poor adherence or inadequate treatment earlier than 2 months after treatment initiation. Inadequate treatment leads to worsening disease, disease transmission and drug resistance.
| Type: | Article |
|---|---|
| Title: | Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0046191 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0046191 |
| Language: | English |
| Additional information: | © Bloom et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Sources of funding were the Medical Research Council (U117565642), Institute Merieux, European Union and Wellcome Trust (088316 and 084323). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. A U.S. patent has been assigned for the findings in this manuscript. Title: Early Detection of Tuberculosis Treatment Response. Serial No.: 61/610,121. Filing Date: March 13, 2012. The authors declare that co-author Robert J Wilkinson is a PLOS ONE Editorial Board member. They also confirm that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the PLOS ONE guide for authors and therefore will not alter their policy on data-sharing and materials. The authors declare their patent with details as shown here. U.S. Patent Application. Title: Early Detection of Tuberculosis Treatment Response. Serial No.: 61/610,121. Filing Date: March 13, 2012. Our File No.: BHCS:1146. There are no other relevant declarations relating to employment, consultancy, patents, products in development or modified products etc. Furthermore, the authors also confirm that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. Dr. Jacques Banchereau no longer works at Hoffmann-La Roche Inc. as of the last month, but is still affiliated with Baylor Institute for Immunology Research. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1384664 |
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