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A well-characterised peak identification list of MALDI MS profile peaks for human blood serum

Tiss, A; Smith, C; Menon, U; Jacobs, I; Timms, JF; Cramer, R; (2010) A well-characterised peak identification list of MALDI MS profile peaks for human blood serum. Proteomics , 10 (18) 3388 - 3392. 10.1002/pmic.201000100. Green open access

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Abstract

MALDI MS profiling, using easily available body fluids such as blood serum, has attracted considerable interest for its potential in clinical applications. Despite the numerous reports on MALDI MS profiling of human serum, there is only scarce information on the identity of the species making up these profiles, particularly in the mass range of larger peptides. Here, we provide a list of more than 90 entries of MALDI MS profile peak identities up to 10 kDa obtained from human blood serum. Various modifications such as phosphorylation were detected among the peptide identifications. The overlap with the few other MALDI MS peak lists published so far was found to be limited and hence our list significantly extends the number of identified peaks commonly found in MALDI MS profiling of human blood serum.

Type: Article
Title: A well-characterised peak identification list of MALDI MS profile peaks for human blood serum
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/pmic.201000100
Publisher version: http://dx.doi.org/10.1002/pmic.201000100
Language: English
Additional information: This is the peer reviewed version of the following article: Tiss, A; Smith, C; Menon, U; Jacobs, I; Timms, JF; Cramer, R; (2010) A well-characterised peak identification list of MALDI MS profile peaks for human blood serum. PROTEOMICS, 10 (18) 3388 - 3392., which has been published in final form at http://dx.doi.org/10.1002/pmic.201000100. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-820227.html).
Keywords: MALDI, MS/MS peak identification, serum profiling, technology, mass spectrometry, pancreatic cancer, plasma proteome, ovarian cancer, proteins, peptides, biomarkers, enrichment, carcinoma, diagnosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery.ucl.ac.uk/id/eprint/138395
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