Boldrin, L;
Morgan, JE;
(2013)
Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle.
PLoS One
, 8
(1)
, Article e54599. 10.1371/journal.pone.0054599.
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Abstract
Skeletal muscle has a remarkable capability of regeneration following injury. Satellite cells, the principal muscle stem cells, are responsible for this process. However, this regenerative capacity is reduced in muscular dystrophies or in old age: in both these situations, there is a net loss of muscle fibres. Promoting skeletal muscle muscle hypertrophy could therefore have potential applications for treating muscular dystrophies or sarcopenia. Here, we observed that muscles of dystrophic mdx nude host mice that had been acutely injured by myotoxin and grafted with a single myofibre derived from a normal donor mouse exhibited increased muscle area. Transplantation experiments revealed that the hypertrophic effect is mediated by the grafted fibre and does not require either an imposed injury to the host muscle, or the contribution of donor cells to the host muscle. These results suggest the presence of a crucial cross-talk between the donor fibre and the host muscle environment.
| Type: | Article |
|---|---|
| Title: | Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0054599 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0054599 |
| Language: | English |
| Additional information: | © 2013 Boldrin, Morgan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by: Wellcome Trust University Award grant number: 08241/Z/07/Z (http://www.wellcome.ac.uk/); Muscular Dystrophy Campaign grant number: RA3/776 (http://www.muscular-dystrophy.org/); Association Francaise contre les Myopathies grant number: 13948 (http://www.afm-telethon.fr/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1383947 |
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