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Incidence of end-stage renal disease in the Turkish-cypriot population of northern cyprus: a population based study.

Connor, TM; Oygar, DD; Gale, DP; Steenkamp, R; Nitsch, D; Neild, GH; Maxwell, PH; (2013) Incidence of end-stage renal disease in the Turkish-cypriot population of northern cyprus: a population based study. PLoS One , 8 (1) , Article e54394. 10.1371/journal.pone.0054394. Green open access

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Abstract

Background This is the first report of the incidence and causes of end-stage renal disease (ESRD) of the Turkish-Cypriot population in Northern Cyprus. Methods Data were collected over eight consecutive years (2004–2011) from all those starting renal replacement therapy (RRT) in this population. Crude and age-standardised incidence at 90 days was calculated and comparisons made with other national registries. We collected DNA from the entire prevalent population. As an initial experiment we looked for two genetic causes of ESRD that have been reported in Greek Cypriots. Results Crude and age-standardised incidence at 90 days was 234 and 327 per million population (pmp) per year, respectively. The mean age was 63, and 62% were male. The age-adjusted prevalence of RRT in Turkish-Cypriots was 1543 pmp on 01/01/2011. The incidence of RRT is higher than other countries reporting to the European Renal Association – European Dialysis and Transplant Association, with the exception of Turkey. Diabetes is a major cause of ESRD in those under 65, accounting for 36% of incident cases followed by 30% with uncertain aetiology. 18% of the incident population had a family history of ESRD. We identified two families with thin basement membrane nephropathy caused by a mutation in COL4A3, but no new cases of CFHR5 nephropathy. Conclusions This study provides the first estimate of RRT incidence in the Turkish-Cypriot population, describes the contribution of different underlying diagnoses to ESRD, and provides a basis for healthcare policy planning.

Type: Article
Title: Incidence of end-stage renal disease in the Turkish-cypriot population of northern cyprus: a population based study.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0054394
Publisher version: http://dx.doi.org/10.1371/journal.pone.0054394
Language: English
Additional information: © 2013 Connor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by a Clinical Research Training Fellowship to TMFC from the Medical Research Council (http://www.mrc.ac.uk/index.htm) and a grant from the St Peter’s Trust for Kidney, Bladder and Prostate Research (http://www.stpeterstrust.org.uk/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1383864
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