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The Tn916/Tn1545 Family of Conjugative Transposon

Ciric, L; Jasni, A; de Vries, EL; Agerso, Y; Mullany, P; Roberts, AP; (2013) The Tn916/Tn1545 Family of Conjugative Transposon. In: Roberts, AP and Mullany, P, (eds.) Bacterial Integrative Mobile Genetic Elements. (pp. 153-170). Landes Bioscience: Austin, US. Green open access

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Abstract

The conjugative transposon Tn916 was first discovered in the late 1970s and is, together with the related conjugative transposon Tn1545, the paradigm of a large family of related conjugative transposons known as the Tn916/Tn1545 family, which are found in an extremely diverse range of bacteria. With the huge increase in bacterial genomic sequence data available, due to the widespread use of next generation sequencing, more putative conjugative transposons belonging to the Tn916/Tn1545 family are being reported. Many of these are capable of excision, integration and conjugation. Nearly all of the Tn916/Tn1545‑like elements discovered to date encode tetracycline resistance however, increasingly resistance to other antimicrobials is being found. Some of the members of the Tn916/Tn1545 family of elements are composite structures which contain smaller mobile genetic elements which are also capable of transposition. Tn916/Tn1545‑like elements themselves are also found within larger and more complex elements. This review will give an overview of the current knowledge of the Tn916/Tn1545 family of conjugative transposons highlighting recently characterized composite elements carrying additional and novel resistance genes.

Type: Book chapter
Title: The Tn916/Tn1545 Family of Conjugative Transposon
ISBN-13: 9781587066603
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.landesbioscience.com/books/iu/id/4698/
Language: English
Additional information: This chapter is reproduced with copyright permission from: Ciric L, Jasni A, de Vries EL, Agerso Y, Mullany P, Roberts AP. The Tn916/Tn1545 family of conjugative transposons. In: Roberts AP, Mullany P, eds. Bacterial Integrative Mobile Genetic Elements. Austin: Landes Bioscience, 2013:153-170. © 2011 Landes Bioscience. Not for distribution. Figures 1, 2 and 5 removed for copyright reasons.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Civil, Environ and Geomatic Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1383521
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