UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Preparation of porous microsphere-scaffolds by electrohydrodynamic forming and thermally induced phase separation.

Ghanbar, H; Luo, CJ; Bakhshi, P; Day, R; Edirisinghe, M; (2013) Preparation of porous microsphere-scaffolds by electrohydrodynamic forming and thermally induced phase separation. Mater Sci Eng C Mater Biol Appl , 33 (5) 2488 - 2498. 10.1016/j.msec.2012.12.098. Green open access

[img]
Preview
PDF
1-s2.0-S0928493113000118-main.pdf

Download (3MB)

Abstract

The availability of forming technologies able to mass produce porous polymeric microspheres with diameters ranging from 150 to 300 μm is significant for some biomedical applications where tissue augmentation is required. Moreover, appropriate assembly of microspheres into scaffolds is an important challenge to enable direct usage of the as-formed structures in treatments. This work reports the production of poly (glycolic-co-lactic acid) and poly (ε-caprolactone) microspheres under ambient conditions using one-step electrohydrodynamic jetting (traditionally known as atomisation) and thermally induced phase separation (TIPS). To ensure robust production for practical uses, this work presents 12 comprehensive parametric mode mappings of the diameter distribution profiles of the microspheres obtained over a broad range of key processing parameters and correlating of this with the material parameters of 5 different polymer solutions of various concentrations. Poly (glycolic-co-lactic acid) (PLGA) in Dimethyl carbonate (DMC), a low toxicity solvent with moderate conductivity and low dielectric constant, generated microspheres within the targeted diameter range of 150-300 μm. The fabrication of the microspheres suitable for formation of the scaffold structure is achieved by changing the collection method from distilled water to liquid nitrogen and lyophilisation in a freeze dryer.

Type: Article
Title: Preparation of porous microsphere-scaffolds by electrohydrodynamic forming and thermally induced phase separation.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.msec.2012.12.098
Publisher version: http://dx.doi.org/10.1016/j.msec.2012.12.098
Language: English
Additional information: © 2013 Elsevier B.V. All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License.
Keywords: Microspheres, Particle Size, Polymers
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1380443
Downloads since deposit
159Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item