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Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis

Nistala, K; Varsani, H; Wittkowski, H; Vogl, T; Krol, P; Shah, V; Mamchaoui, K; ... Wedderburn, LR; + view all (2013) Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis. Arthritis Research & Therapy , 15 (5) , Article R131. 10.1186/ar4311. Green open access

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Abstract

The aetiopathogenesis of juvenile dermatomyositis (JDM) remains poorly understood. In particular the contribution of monocytes or macrophages, which are frequently observed to be an infiltrate within muscle tissue very early in the disease process, is unknown. We hypothesised that these cells secrete the pro-inflammatory myeloid related protein (MRP) 8/14 which may then contribute to muscle pathology in JDM.

Type: Article
Title: Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/ar4311
Publisher version: http://dx.doi.org/10.1186/ar4311
Language: English
Additional information: © 2013 Nistala et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > ICH - Laboratory Management
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1380175
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