Menalled, LB;
Patry, M;
Ragland, N;
Lowden, PA;
Goodman, J;
Minnich, J;
Zahasky, B;
... Brunner, D; + view all
(2012)
Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline.
PLoS One
, 5
, Article e9793. 10.1371/journal.pone.0009793.
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Abstract
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington's disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and testing for mouse models of Huntington's disease, we report that neither coenzyme Q10 nor minocycline had significant beneficial effects on measures of motor function, general health (open field, rotarod, grip strength, rearing-climbing, body weight and survival) in the R6/2 mouse model. The higher doses of minocycline, on the contrary, reduced survival. We were thus unable to confirm the previously reported benefits for these two drugs, and we discuss potential reasons for these discrepancies, such as the effects of husbandry and nutrition.
| Type: | Article |
|---|---|
| Title: | Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0009793 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0009793 |
| Language: | English |
| Additional information: | © 2010 Menalled et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Animals Anti-Bacterial Agents Behavior, Animal Body Weight Disease Models, Animal Female Hand Strength Huntington Disease Male Mice Mice, Inbred C57BL Mice, Inbred DBA Minocycline Motor Skills Ubiquinone |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1380171 |
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