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Treatment of high risk Sertoli-Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog

Lashkari, HP; Nash, R; Albanese, A; Okoye, B; Millar, R; Pritchard-Jones, K; (2013) Treatment of high risk Sertoli-Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog. Pediatric Blood & Cancer , 60 (6) E16 - E18. 10.1002/pbc.24382. Green open access

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Abstract

Sertoli-Leydig cell tumors are rare ovarian neoplasms. We report two unusual cases with bilateral SLCTs suggesting evidence of genetic predisposition and at high risk of recurrence. To reduce this risk, we exploited the use of GnRH analog to lower gondadotropin and potentially directly inhibit the tumors through expressed GnRH receptors. We used it as maintenance antitumor therapy for 2 years after completion of chemotherapy, to cover the period of risk for recurrence. Both patients remain in complete remission at >2 years after completing leuprorelin therapy. Of note, both patients carry DICER1 mutations, frequently found in pleuropulmonary blastoma syndrome.

Type: Article
Title: Treatment of high risk Sertoli-Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/pbc.24382
Publisher version: http://dx.doi.org/10.1002/pbc.24382
Language: English
Additional information: Wiley OnlineOpen article. Copyright © 2012 Wiley Periodicals, Inc
Keywords: Antineoplastic Agents, Hormonal, Child, Female, Gonadotropin-Releasing Hormone, Humans, Leuprolide, Neoplasm Recurrence, Local, Ovarian Neoplasms, Sertoli-Leydig Cell Tumor
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1379259
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