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Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited

Sandercock, P; Lindley, R; Wardlaw, J; Dennis, M; Innes, K; Cohen, G; Whiteley, W; ... IST-3 collaborative group, ; + view all (2011) Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited. Trials , 12 , Article 252. 10.1186/1745-6215-12-252. Green open access

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Abstract

Intravenous recombinant tissue plasminogen activator (rtPA) is approved in Europe for use in patients with acute ischaemic stroke who meet strictly defined criteria. IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to determine whether a wider range of patients might benefit.

Type: Article
Title: Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1745-6215-12-252
Publisher version: http://dx.doi.org/10.1186/1745-6215-12-252
Language: English
Additional information: © 2011 Sandercock et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3286387
Keywords: Acute Disease, Brain Ischemia, Double-Blind Method, Fibrinolytic Agents, Humans, Prospective Studies, Sample Size, Stroke, Thrombolytic Therapy, Tissue Plasminogen Activator
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1379040
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