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Brain glutamate and gamma-aminobutyrate (GABA) metabolism in thiamin-deficient rats

Page, MG; Ankoma-Sey, V; Coulson, WF; Bender, DA; (1989) Brain glutamate and gamma-aminobutyrate (GABA) metabolism in thiamin-deficient rats. British Journal of Nutrition , 62 (2) 245 - 253. 10.1079/BJN19890027. Green open access

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Abstract

The brain metabolism of glutamate and gamma-aminobutyrate (GABA) was investigated in thiamin-deficient and pair-fed control rats, in order to determine whether the GABA shunt may provide an important alternative to 2-oxo-glutarate dehydrogenase (EC 1.2.4.2) in energy-yielding metabolism in thiamin deficiency. Brains from thiamin-deficient animals contained less glutamate, 2-oxo-glutarate and GABA than those from control animals. The brain content of ATP was unaffected by thiamin deficiency. After intracerebroventricular injection of [14C]glutamate, the specific radioactivity of GABA in the brains from deficient animals was 45-50% higher than that in controls, suggesting a considerable increase in the metabolic flux through the GABA shunt in thiamin deficiency. Brain GABA showed a marked circumannual variation, with a peak in mid-summer and a minimum value in mid-winter.

Type: Article
Title: Brain glutamate and gamma-aminobutyrate (GABA) metabolism in thiamin-deficient rats
Open access status: An open access version is available from UCL Discovery
DOI: 10.1079/BJN19890027
Publisher version: http://dx.doi.org/10.1079/BJN19890027
Language: English
Additional information: © 1989 Cambridge University Press
Keywords: Animals, Brain, metabolism, Glutamates, Male, Rats, Inbred Strains, Thiamine Deficiency, gamma-Aminobutyric Acid
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/137897
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