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Sub-second dopamine detection in human striatum.

Kishida, KT; Sandberg, SG; Lohrenz, T; Comair, YG; Sáez, I; Phillips, PE; Montague, PR; (2011) Sub-second dopamine detection in human striatum. PLoS One , 6 (8) , Article e23291. 10.1371/journal.pone.0023291. Green open access

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Abstract

Fast-scan cyclic voltammetry at carbon fiber microelectrodes allows rapid (sub-second) measurements of dopamine release in behaving animals. Herein, we report the modification of existing technology and demonstrate the feasibility of making sub-second measurements of dopamine release in the caudate nucleus of a human subject during brain surgery. First, we describe the modification of our electrodes that allow for measurements to be made in a human brain. Next, we demonstrate in vitro and in vivo, that our modified electrodes can measure stimulated dopamine release in a rat brain equivalently to previously determined rodent electrodes. Finally, we demonstrate acute measurements of dopamine release in the caudate of a human patient during DBS electrode implantation surgery. The data generated are highly amenable for future work investigating the relationship between dopamine levels and important decision variables in human decision-making tasks.

Type: Article
Title: Sub-second dopamine detection in human striatum.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0023291
Publisher version: http://dx.doi.org/10.1371/journal.pone.0023291
Language: English
Additional information: This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. This work was supported by the NIH DA024140 (PRM & PEMP), DA11723 (PRM), T32-NS43124 (KTK), the Parkinson's Disease Foundation (SGS), the Brown Foundation (PRM), and the Wellcome Trust Principal Research Fellowship (PRM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Animals, Corpus Striatum, Deep Brain Stimulation, Dopamine, Humans, Rats
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/1378408
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