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Hmgb3 is regulated by microrna-206 during muscle regeneration.

Maciotta, S; Meregalli, M; Cassinelli, L; Parolini, D; Farini, A; Fraro, GD; Gandolfi, F; ... Torrente, Y; + view all (2012) Hmgb3 is regulated by microrna-206 during muscle regeneration. PLoS One , 7 (8) , Article e43464. 10.1371/journal.pone.0043464. Green open access

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Abstract

MicroRNAs (miRNAs) have been recently involved in most of human diseases as targets for potential strategies to rescue the pathological phenotype. Since the skeletal muscle is a spread-wide highly differentiated and organized tissue, rescue of severely compromised muscle still remains distant from nowadays. For this reason, we aimed to identify a subset of miRNAs major involved in muscle remodelling and regeneration by analysing the miRNA-profile of single fibres isolated from dystrophic muscle, which was here considered as a model of chronic damage.

Type: Article
Title: Hmgb3 is regulated by microrna-206 during muscle regeneration.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0043464
Publisher version: http://dx.doi.org/10.1371/journal.pone.0043464
Language: English
Additional information: © Maciotta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported in part by grants from the Association Monégasque contre les Myopathies (AMM), EU's Framework programme 7 Optistem 223098, the Associazione La Nostra Famiglia Fondo DMD Gli Amici di Emanuele, and by the Associazione Amici del Centro Dino Ferrari. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1378059
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