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Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity

Tillo, M; Ruhrberg, C; Mackenzie, F; (2012) Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity. Cell Adhesion & Migration , 6 (6) 541 - 546. 10.4161/cam.22408. Green open access

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Abstract

Synapse formation, maintenance and plasticity are critical for the correct function of the nervous system and its target organs. During development, these processes enable the establishment of appropriate neural circuits. During adulthood, they allow adaptation to both physiological and environmental changes. In this review, we discuss emerging roles for two families of classical axon and vascular guidance cues in synaptogenesis and synaptic plasticity, the semaphorins and the vascular endothelial growth factors (VEGFs). Their contribution to synapse formation and function add a new facet to the spectrum of overlapping and complementary roles for these molecules in development, adulthood and disease.

Type: Article
Title: Emerging roles for semaphorins and VEGFs in synaptogenesis and synaptic plasticity
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.4161/cam.22408
Publisher version: http://dx.doi.org/10.4161/cam.22408
Language: English
Additional information: © 2012 Landes Bioscience. This work is licensed under the Creative Commons Attribution License, Attribution 3.0 Unported (CC BY 3.0) http://creativecommons.org/licenses/by/3.0/ which permits unrestricted use, distribution, and reproduction in any medium. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work). PMCID: PMC3547901
Keywords: Semaphorin, VEGF, Synapse, Plasticity, Synaptogenesis, Blood vessel
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1377999
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