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Contrast and stability of the axon diameter index from microstructure imaging with diffusion MRI.

Dyrby, TB; Sogaard, LV; Hall, MG; Ptito, M; Alexander, DC; (2013) Contrast and stability of the axon diameter index from microstructure imaging with diffusion MRI. Magn Reson Med , 70 (3) 711 - 721. 10.1002/mrm.24501. Green open access

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Abstract

The ActiveAx technique fits the minimal model of white matter diffusion to diffusion MRI data acquired using optimized protocols that provide orientationally invariant indices of axon diameter and density. We investigated how limitations of the available maximal gradient strength (Gmax) on a scanner influence the sensitivity to a range of axon diameters. Multishell high-angular-diffusion-imaging (HARDI) protocols for Gmax of 60, 140, 200, and 300 mT/m were optimized for the pulsed-gradient-spin-echo (PGSE) sequence. Data were acquired on a fixed monkey brain and Monte-Carlo simulations supported the results. Increasing Gmax reduces within-voxel variation of the axon diameter index and improves contrast beyond what is achievable with higher signal-to-noise ratio. Simulations reveal an upper bound on the axon diameter (∼10 μm) that pulsed-gradient-spin-echo measurements are sensitive to, due to a trade-off between short T2 and the long diffusion time needed to probe larger axon diameters. A lower bound (∼2.5 μm) slightly dependent on Gmax was evident, below which axon diameters are identifiable as small, but impossible to differentiate. These results emphasize the key-role of Gmax for enhancing contrast between axon diameter distributions and are, therefore, relevant in general for microstructure imaging methods and highlight the need for increased Gmax on future commercial systems.

Type: Article
Title: Contrast and stability of the axon diameter index from microstructure imaging with diffusion MRI.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mrm.24501
Publisher version: http://dx.doi.org/10.1002/mrm.24501
Language: English
Additional information: Copyright © 2012 Copenhagen University Hospital Hvidovre. Magnetic Resonance in Medicine Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: ActiveAx, AxCaliber, DTI, brain, magnetic resonance imaging, model, monkey
UCL classification: UCL
UCL > Provost and Vice Provost Offices
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UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1377661
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