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Skin regeneration scaffolds: a multimodal bottom-up approach.

Yildirimer, L; Thanh, NT; Seifalian, AM; (2012) Skin regeneration scaffolds: a multimodal bottom-up approach. Trends in Biotechnology , 30 (12) 638 - 648. 10.1016/j.tibtech.2012.08.004. Green open access

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Abstract

Skin wounds are a major social and financial burden. However, current treatments are suboptimal. The gradual comprehension of the finely orchestrated nature of intercellular communication has stimulated scientists to investigate growth factor (GF) or stem cell (SC) incorporation into suitable scaffolds for local delivery into wound beds in an attempt to accelerate healing. This review provides a critical evaluation of the status quo of current research into GF and SC therapy and subsequent future prospects, including benefits and possible long-term dangers associated with their use. Additionally, we stress the importance of a bottom-up approach in scaffold fabrication to enable controlled factor incorporation as well as production of complex scaffold micro- and nanostructures resembling that of natural extracellular matrix.

Type: Article
Title: Skin regeneration scaffolds: a multimodal bottom-up approach.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tibtech.2012.08.004
Publisher version: http://dx.doi.org/10.1016/j.tibtech.2012.08.004
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Animals, Humans, Nanotechnology, Regeneration, Skin Physiological Phenomena, Skin, Artificial, Tissue Engineering, Tissue Scaffolds
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/1376579
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