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The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research.

Patterson-Kane, JC; Becker, DL; Rich, T; (2012) The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research. Journal of Comparative Pathology , 147 (2-3) 227 - 247. 10.1016/j.jcpa.2012.05.010. Green open access

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Abstract

The equine superficial digital flexor tendon (SDFT) is a frequently injured structure that is functionally and clinically equivalent to the human Achilles tendon (AT). Both act as critical energy-storage systems during high-speed locomotion and can accumulate exercise- and age-related microdamage that predisposes to rupture during normal activity. Significant advances in understanding of the biology and pathology of exercise-induced tendon injury have occurred through comparative studies of equine digital tendons with varying functions and injury susceptibilities. Due to the limitations of in-vivo work, determination of the mechanisms by which tendon cells contribute to and/or actively participate in the pathogenesis of microdamage requires detailed cell culture modelling. The phenotypes induced must ultimately be mapped back to the tendon tissue environment. The biology of tendon cells and their matrix, and the pathological changes occurring in the context of early injury in both horses and people are reviewed, with a particular focus on the use of various tendon cell and tissue culture systems to model these events.

Type: Article
Title: The pathogenesis of tendon microdamage in athletes: the horse as a natural model for basic cellular research.
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jcpa.2012.05.010
Publisher version: http://dx.doi.org/10.1016/S0140-6736(11)61506-7
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Achilles Tendon, Animals, Athletic Injuries, Disease Models, Animal, Horse Diseases, Horses, Humans, Lameness, Animal, Research Design, Rupture, Tendon Injuries
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1376279
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