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Feasibility study to inform the design of a randomised controlled trial to eradicate Pseudomonas aeruginosa infection in individuals with cystic fibrosis

Hickey, HR; Jones, AP; Lenney, W; Williamson, PR; Smyth, RL; (2010) Feasibility study to inform the design of a randomised controlled trial to eradicate Pseudomonas aeruginosa infection in individuals with cystic fibrosis. Trials , 11 , Article 11. 10.1186/1745-6215-11-11. Green open access

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Abstract

There are controversies about the most effective treatment to eradicate first growth of Pseudomonas aeruginosa (P aeruginosa) from the lower airways of patients with cystic fibrosis (CF). UK guidelines recommend oral treatment, but some advocate intravenous (IV) treatment. The objective of this study was to assess the feasibility of conducting a randomised controlled trial comparing two treatment strategies to eradicate P aeruginosa in CF patients.

Type: Article
Title: Feasibility study to inform the design of a randomised controlled trial to eradicate Pseudomonas aeruginosa infection in individuals with cystic fibrosis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1745-6215-11-11
Publisher version: http://dx.doi.org/10.1186/1745-6215-11-11
Language: English
Additional information: © 2010 Hickey et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC2832639
Keywords: Administration, Oral, Adolescent, Adult, Anti-Bacterial Agents, Child, Cystic Fibrosis, Feasibility Studies, Female, Great Britain, Humans, Male, Middle Aged, Multicenter Studies as Topic, Patient Selection, Pseudomonas Infections, Pseudomonas aeruginosa, Questionnaires, Randomized Controlled Trials as Topic, Respiratory Tract Infections, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1375475
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