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Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people

Sinha, IP; Gallagher, R; Williamson, PR; Smyth, RL; (2012) Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people. Trials , 13 , Article 103. 10.1186/1745-6215-13-103. Green open access

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Abstract

In clinical trials in childhood asthma, outcomes reflecting short-term disease activity are frequently measured, whilst functional status, quality of life (QoL), and long-term treatment effects are rarely assessed. There is also non-uniformity across studies in the selection and measurement of outcomes within these domains. The development of a core outcome set has the potential to reduce heterogeneity between trials, lead to research that is more likely to have measured relevant outcomes, and enhance the value of evidence synthesis by reducing the risk of outcome reporting bias and ensuring that all trials contribute usable information.

Type: Article
Title: Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1745-6215-13-103
Publisher version: http://dx.doi.org/10.1186/1745-6215-13-103
Language: English
Additional information: © 2012 Sinha et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3433381
Keywords: Adolescent, Age Factors, Anti-Asthmatic Agents, Asthma, Child, Child, Preschool, Clinical Trials as Topic, Delphi Technique, Disease Progression, Endpoint Determination, Humans, Nurse Clinicians, Outcome Assessment (Health Care), Parents, Physicians, Quality of Life, Questionnaires, Research Design, Treatment Outcome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1375459
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