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Inhibition of tryptophan metabolism by oestrogens in the rat: a factor in the aetiology of pellagra

Bender, DA; Totoe, L; (1984) Inhibition of tryptophan metabolism by oestrogens in the rat: a factor in the aetiology of pellagra. British Journal of Nutrition , 51 (2) 219 - 224. 10.1079/BJN19840026. Green open access

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Abstract

The effect of the administration of oestrone sulphate on tryptophan metabolism has been assessed in rats in order to determine whether and to what extent inhibition of tryptophan metabolism by oestrogens may be a factor in the aetiology of pellagra, and might explain the reported twofold excess of females over males in many outbreaks of pellagra. Feeding ovariectomized rats for 1 week on a diet containing 15 mg oestrone sulphate/kg led to significant inhibition of kynurenine hydroxylase (EC 1.14.13.9), kynureninase (EC 3.7.1.3) and 3-hydroxyanthranilate oxidase (EC 1.13.11.6). There was also a significant increase in plasma tryptophan, suggesting decreased activity of tryptophan oxygenase (EC 1.13.11.11). This inhibition of tryptophan metabolism will result in a considerable reduction in the synthesis of the nicotinamide nucleotide coenzymes (NAD and NADP) from tryptophan. When ovariectomized rats were maintained for 4 weeks on a diet providing no preformed niacin and only a marginally adequate amount of tryptophan (1030 mg/kg), the addition of sulphate to the diet led to a significant reduction in the liver content of nicotinamide nucleotides and the urinary excretion of the end-product of NAD metabolism, N1-methyl nicotinamide. It is suggested that when the diet is only marginally adequate in tryptophan and niacin, inhibition of tryptophan metabolism by endogenous or administered oestrogens may be an additional factor in the development of pellagra.

Type: Article
Title: Inhibition of tryptophan metabolism by oestrogens in the rat: a factor in the aetiology of pellagra
Open access status: An open access version is available from UCL Discovery
DOI: 10.1079/BJN19840026
Publisher version: http://dx.doi.org/10.1079/BJN19840026
Language: English
Additional information: © 1984 Cambridge University Press
Keywords: Animals, Castration, Estrone, analogs & derivatives, toxicity, Female, Liver, enzymology, NAD, metabolism, NADP, Niacinamide, urine, Pellagra, etiology, Rats, Inbred Strains, Tryptophan
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/137522
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