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Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial.

Gibb, DM; Kizito, H; Russell, EC; Chidziva, E; Zalwango, E; Nalumenya, R; Spyer, M; ... DART trial team, The; + view all (2012) Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial. PLoS Medicine , 9 (5) , Article e1001217. 10.1371/journal.pmed.1001217. Green open access

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Abstract

Few data have described long-term outcomes for infants born to HIV-infected African women taking antiretroviral therapy (ART) in pregnancy. This is particularly true for World Health Organization (WHO)-recommended tenofovir-containing first-line regimens, which are increasingly used and known to cause renal and bone toxicities; concerns have been raised about potential toxicity in babies due to in utero tenofovir exposure.

Type: Article
Title: Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial.
Location: US
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pmed.1001217
Publisher version: http://dx.doi.org/10.1371/journal.pmed.1001217
Language: English
Additional information: © 2012 Gibb et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3352861
Keywords: Abortion, Spontaneous, Adenine, Adult, Anti-HIV Agents, Body Height, Body Weight, Breast Feeding, Burns, Cause of Death, Child, Preschool, Congenital Abnormalities, Drug Combinations, Female, Follow-Up Studies, Fractures, Bone, Growth, HIV Infections, HIV Seropositivity, Humans, Infant, Infant Mortality, Infant, Newborn, Infectious Disease Transmission, Vertical, Lamivudine, Male, Measles, Organophosphonates, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Prevalence, Respiratory Tract Infections, Uganda, Zidovudine, Zimbabwe
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1373459
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