UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy?

Ahmed, Hashim Uddin; Arya, Manit; Freeman, Alex; Emberton, Mark; (2012) Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy? The Lancet Oncology , 13 (11) e509 - e517. 10.1016/S1470-2045(12)70388-1. Green open access

[thumbnail of 1373135.pdf]
Preview
Text
1373135.pdf

Download (602kB)

Abstract

Prostate cancer is generally multifocal and consists of a dominant focus-measured by tumour volume and deemed the index lesion-and one or more separate, secondary tumour foci of smaller volume. Much laboratory and clinical evidence has shown that we need to rethink how we regard low-grade and low-volume prostate lesions. In this Personal View, we discuss why small, low-grade Gleason pattern prostate lesions, which are currently designated as prostate cancer, could be regarded as non-malignant. These lesions either do not meet the criteria of the hallmarks of cancer or robust evidence that they do so is absent, by contrast with large lesions with a high Gleason grade, which seem to cause most metastatic disease.

Type: Article
Title: Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy?
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1470-2045(12)70388-1
Publisher version: http://dx.doi.org/10.1016/S1470-2045(12)70388-1
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1373135
Downloads since deposit
2Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item