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The estimation of patient-specific cardiac diastolic functions from clinical measurements.

Xi, J; Lamata, P; Niederer, S; Land, S; Shi, W; Zhuang, X; Ourselin, S; ... Smith, NP; + view all (2013) The estimation of patient-specific cardiac diastolic functions from clinical measurements. Medical Image Analysis , 17 (2) 133 - 146. 10.1016/j.media.2012.08.001. Green open access

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Abstract

An unresolved issue in patients with diastolic dysfunction is that the estimation of myocardial stiffness cannot be decoupled from diastolic residual active tension (AT) because of the impaired ventricular relaxation during diastole. To address this problem, this paper presents a method for estimating diastolic mechanical parameters of the left ventricle (LV) from cine and tagged MRI measurements and LV cavity pressure recordings, separating the passive myocardial constitutive properties and diastolic residual AT. Dynamic C1-continuous meshes are automatically built from the anatomy and deformation captured from dynamic MRI sequences. Diastolic deformation is simulated using a mechanical model that combines passive and active material properties. The problem of non-uniqueness of constitutive parameter estimation using the well known Guccione law is characterized by reformulation of this law. Using this reformulated form, and by constraining the constitutive parameters to be constant across time points during diastole, we separate the effects of passive constitutive properties and the residual AT during diastolic relaxation. Finally, the method is applied to two clinical cases and one control, demonstrating that increased residual AT during diastole provides a potential novel index for delineating healthy and pathological cases.

Type: Article
Title: The estimation of patient-specific cardiac diastolic functions from clinical measurements.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.media.2012.08.001
Publisher version: http://dx.doi.org/10.1016/j.media.2012.08.001
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1373019
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