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Incidence, clinical spectrum, risk factors and impact of HIV-associated immune reconstitution inflammatory syndrome in South Africa.

Haddow, LJ; Moosa, MY; Mosam, A; Moodley, P; Parboosing, R; Easterbrook, PJ; (2012) Incidence, clinical spectrum, risk factors and impact of HIV-associated immune reconstitution inflammatory syndrome in South Africa. PLOS One , 7 (11) , Article e40623. 10.1371/journal.pone.0040623. Green open access

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Abstract

Immune reconstitution inflammatory syndrome (IRIS) is a widely recognised complication of antiretroviral therapy (ART), but there are still limited data from resource-limited settings. Our objective was to characterize the incidence, clinical spectrum, risk factors and contribution to mortality of IRIS in two urban ART clinics in South Africa.

Type: Article
Title: Incidence, clinical spectrum, risk factors and impact of HIV-associated immune reconstitution inflammatory syndrome in South Africa.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0040623
Publisher version: http://dx.doi.org/10.1371/journal.pone.0040623
Language: English
Additional information: © 2012 Haddow et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The study was funded by the Doris Duke Charitable Foundation (grant number 2006029), the Medical Research Council UK (Clinical Research Training Fellowship number G0700530), and the British Society for Antimicrobial Chemotherapy (Research Grant GA745). PE is a recipient of a UK National Institutes of Health Research Senior Investigator Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1372959
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