UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation.

Morris, SA; Almeida, AD; Tanaka, H; Ohta, K; Ohnuma, S; (2007) Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation. PLOS One , 2 (10) , Article e1004. 10.1371/journal.pone.0001004. Green open access

[thumbnail of 1372826.pdf]
Preview
PDF
1372826.pdf

Download (3MB)

Abstract

Cell-cell communication is essential in tissue patterning. In early amphibian development, mesoderm is formed in the blastula-stage embryo through inductive interactions in which vegetal cells act on overlying equatorial cells. Members of the TGF-beta family such as activin B, Vg1, derrière and Xenopus nodal-related proteins (Xnrs) are candidate mesoderm inducing factors, with further activity to induce endoderm of the vegetal region. TGF-beta-like ligands, including BMP, are also responsible for patterning of germ layers. In addition, FGF signaling is essential for mesoderm formation whereas FGF signal inhibition has been implicated in endoderm induction. Clearly, several signaling pathways are coordinated to produce an appropriate developmental output; although intracellular crosstalk is known to integrate multiple pathways, relatively little is known about extracellular coordination.

Type: Article
Title: Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0001004
Publisher version: http://dx.doi.org/10.1371/journal.pone.0001004
Language: English
Additional information: © 2007 Morris et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Cancer Research UK, Medical Research Council, FCT Portugal, PRESTO Japan
Keywords: Animals, Bone Morphogenetic Proteins, Cell Communication, Endoderm, Fibroblast Growth Factors, Gene Expression Regulation, Developmental, Germ Cells, Germ Layers, Ligands, Mesoderm, Models, Biological, Signal Transduction, Transforming Growth Factor beta, Xenopus Proteins
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1372826
Downloads since deposit
120Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item