Omoyinmi, E;
Forabosco, P;
Hamaoui, R;
Bryant, A;
Hinks, A;
Ursu, S;
Childhood Arthritis Prospective Study (CAPS);
... Woo, P; + view all
(2012)
Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA).
PLOS One
, 7
(10)
, Article e47673. 10.1371/journal.pone.0047673.
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Abstract
The cytokine IL-10 and its family members have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL-10 were associated with a rare group of diseases called juvenile idiopathic arthritis (JIA). The aim of this study was to fine map genetic variants within the IL-10 cytokine family cluster on chromosome 1 using linkage disequilibrium (LD)-tagging single nucleotide polymorphisms (tSNPs) approach with imputation and conditional analysis to test for disease associations.
| Type: | Article |
|---|---|
| Title: | Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA). |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0047673 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0047673 |
| Language: | English |
| Additional information: | © Omoyinmi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported by Arthritis Research UK and by grants from SPARKS UK [08ICH09; the Big Lottery Fund (RG/1/010135231)], and in part by Great Ormond Street Children’s Charity. This study makes use of data generated by the Wellcome Trust Case-Control Consortium 2. A full list of the investigators who contributed to the generation of the data is available from www.wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 076113 and 085475. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1372153 |
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