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State-dependent representation of amplitude-modulated noise stimuli in rat auditory cortex.

Marguet, SL; Harris, KD; (2011) State-dependent representation of amplitude-modulated noise stimuli in rat auditory cortex. Journal of Neuroscience , 31 (17) 6414 - 6420. 10.1523/JNEUROSCI.5773-10.2011. Green open access

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Abstract

Cortical responses can vary greatly between repeated presentations of an identical stimulus. Here we report that both trial-to-trial variability and faithfulness of auditory cortical stimulus representations depend critically on brain state. A frozen amplitude-modulated white noise stimulus was repeatedly presented while recording neuronal populations and local field potentials (LFPs) in auditory cortex of urethane-anesthetized rats. An information-theoretic measure was used to predict neuronal spiking activity from either the stimulus envelope or simultaneously recorded LFP. Evoked LFPs and spiking more faithfully followed high-frequency temporal modulations when the cortex was in a desynchronized state. In the synchronized state, neural activity was poorly predictable from the stimulus envelope, but the spiking of individual neurons could still be predicted from the ongoing LFP. Our results suggest that although auditory cortical activity remains coordinated as a population in the synchronized state, the ability of continuous auditory stimuli to control this activity is greatly diminished.

Type: Article
Title: State-dependent representation of amplitude-modulated noise stimuli in rat auditory cortex.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.5773-10.2011
Publisher version: http://dx.doi.org/10.1523/JNEUROSCI.5773-10.2011
Language: English
Additional information: This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. PMCID: PMC3099304
Keywords: Acoustic Stimulation, Action Potentials, Animals, Auditory Cortex, Electroencephalography, Evoked Potentials, Auditory, Male, Neurons, Noise, Predictive Value of Tests, Probability, Rats, Rats, Sprague-Dawley, Spectrum Analysis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1371976
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