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Oscillations in cerebral haemodynamics in patients with falciparum malaria.

Kolyva, C; Kingston, H; Tachtsidis, I; Mohanty, S; Mishra, S; Patnaik, R; Maude, RJ; ... Elwell, CE; + view all (2013) Oscillations in cerebral haemodynamics in patients with falciparum malaria. Adv Exp Med Biol , 765 101 - 107. 10.1007/978-1-4614-4989-8_15. Green open access

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Abstract

Spontaneous oscillations in cerebral haemodynamics studied with near-infrared spectroscopy (NIRS), become impaired in several pathological conditions. We assessed the spectral characteristics of these oscillations in 20 patients with falciparum malaria admitted to Ispat General Hospital, Rourkela, India. Monitoring included continuous frontal lobe NIRS recordings within 24 h of admission (Day 0), together with single measurements of a number of clinical and chemical markers recorded on admission. Seven patients returned for follow-up measurements on recovery (FU). A 2,048 sampling-point segment of oxygenated haemoglobin concentration ([ΔHbO(2)]) data was subjected to Fourier analysis per patient, and power spectral density was derived over the very low frequency (VLF: 0.02-0.04 Hz), low frequency (LF: 0.04-0.15 Hz) and high frequency (HF: 0.15-0.4 Hz) bands. At Day 0, VLF spectral power was 21.1 ± 16.4, LF power 7.2 ± 4.6 and HF power 2.6 ± 5.0, with VLF power being statistically significantly higher than LF and HF (P < 0.005). VLF power tended to decrease in the severely ill patients and correlated negatively with heart rate (r = 0.57, P < 0.01), while LF power correlated positively with aural body temperature (r = 0.49, P < 0.05). In all but one of the patients who returned for FU measurements, VLF power increased after recovery. This may be related to autonomic dysfunction in severe malaria, a topic of little research to date. The present study demonstrated that application of NIRS in a resource-poor setting is feasible and has potential as a research tool.

Type: Article
Title: Oscillations in cerebral haemodynamics in patients with falciparum malaria.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4614-4989-8_15
Publisher version: http://dx.doi.org/10.1007/978-1-4614-4989-8_15
Language: English
Additional information: © Springer Science+Business Media New York 2013. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Adult, Aged, Brain, Cerebrovascular Circulation, Electrocardiography, Fourier Analysis, Heart Rate, Hemodynamics, Humans, India, Malaria, Falciparum, Male, Middle Aged, Plasmodium falciparum, Signal Processing, Computer-Assisted, Spectroscopy, Near-Infrared, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1371837
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