Balk, LJ;
de Vries-Knoppert, WA;
Petzold, A;
(2012)
A Simple Sign for Recognizing Off-Axis OCT Measurement Beam Placement in the Context of Multicentre Studies.
PLoS One
, 7
(11)
, Article e48222. 10.1371/journal.pone.0048222.
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2012-oct-horizontal-PLoSone.pdf Available under License : See the attached licence file. Download (1MB) |
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MP4 video (Video S1: Live coverage of the effect of off axis measurement beam placement.)
Off_Axis_OCT_Measurement_Beam_Placement.mp4 Download (152MB) |
Abstract
Optical coherence tomography (OCT) allows quantification of the thickness of the retinal nerve fibre layer (RNFL) thickness, a potential biomarker for neurodegeneration. The estimated annual RNFL loss in multiple sclerosis amounts to 2 μm using time domain OCT. The recognition of measurement artifacts exceeding this limit is relevant for the successful use of OCT as a secondary outcome measure in clinical trials.
| Type: | Article |
|---|---|
| Title: | A Simple Sign for Recognizing Off-Axis OCT Measurement Beam Placement in the Context of Multicentre Studies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0048222 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0048222 |
| Language: | English |
| Additional information: | © 2012 Balk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3493550. Video S1: Live coverage of the effect of off axis measurement beam placement: This video shows the situation of off-centre beam placement, with the live OCT image in the acquisition window. This image shows the artifacts caused by temporal, nasal, inferior and superior off-centre placement of the measurement beam.(WMV) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1370629 |
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