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The effect of motivation on movement: a study of bradykinesia in Parkinson's disease.

Shiner, T; Seymour, B; Symmonds, M; Dayan, P; Bhatia, KP; Dolan, RJ; (2012) The effect of motivation on movement: a study of bradykinesia in Parkinson's disease. PLOS One , 7 (10) , Article e47138. 10.1371/journal.pone.0047138. Green open access

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Abstract

Bradykinesia is a cardinal feature of Parkinson's disease (PD). Despite its disabling impact, the precise cause of this symptom remains elusive. Recent thinking suggests that bradykinesia may be more than simply a manifestation of motor slowness, and may in part reflect a specific deficit in the operation of motivational vigour in the striatum. In this paper we test the hypothesis that movement time in PD can be modulated by the specific nature of the motivational salience of possible action-outcomes.

Type: Article
Title: The effect of motivation on movement: a study of bradykinesia in Parkinson's disease.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0047138
Publisher version: http://dx.doi.org/10.1371/journal.pone.0047138
Language: English
Additional information: © Shiner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The funders for this study are the MRC who support Tamara Shiner with a clinical research training fellowship grant and the Wellcome trust who support RD with a Wellcome Trust Programme Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1369397
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