Shiner, T;
Seymour, B;
Symmonds, M;
Dayan, P;
Bhatia, KP;
Dolan, RJ;
(2012)
The effect of motivation on movement: a study of bradykinesia in Parkinson's disease.
PLOS One
, 7
(10)
, Article e47138. 10.1371/journal.pone.0047138.
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Abstract
Bradykinesia is a cardinal feature of Parkinson's disease (PD). Despite its disabling impact, the precise cause of this symptom remains elusive. Recent thinking suggests that bradykinesia may be more than simply a manifestation of motor slowness, and may in part reflect a specific deficit in the operation of motivational vigour in the striatum. In this paper we test the hypothesis that movement time in PD can be modulated by the specific nature of the motivational salience of possible action-outcomes.
| Type: | Article |
|---|---|
| Title: | The effect of motivation on movement: a study of bradykinesia in Parkinson's disease. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0047138 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0047138 |
| Language: | English |
| Additional information: | © Shiner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The funders for this study are the MRC who support Tamara Shiner with a clinical research training fellowship grant and the Wellcome trust who support RD with a Wellcome Trust Programme Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1369397 |
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