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Synaptic energy use and supply.

Harris, JJ; Jolivet, R; Attwell, D; (2012) Synaptic energy use and supply. Neuron , 75 (5) 762 - 777. 10.1016/j.neuron.2012.08.019. Green open access

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Abstract

Neuronal computation is energetically expensive. Consequently, the brain's limited energy supply imposes constraints on its information processing capability. Most brain energy is used on synaptic transmission, making it important to understand how energy is provided to and used by synapses. We describe how information transmission through presynaptic terminals and postsynaptic spines is related to their energy consumption, assess which mechanisms normally ensure an adequate supply of ATP to these structures, consider the influence of synaptic plasticity and changing brain state on synaptic energy use, and explain how disruption of the energy supply to synapses leads to neuropathology.

Type: Article
Title: Synaptic energy use and supply.
Location: US
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2012.08.019
Publisher version: http://dx.doi.org/10.1016/j.neuron.2012.08.019
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Animals, Brain, Brain Chemistry, Energy Metabolism, Humans, Neuronal Plasticity, Synaptic Transmission
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1368741
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