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A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded regions in RNA.

Neidle, S; Taylor, G; Sanderson, M; (1978) A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded regions in RNA. Nucleic Acids Res , 5 (11) 4417 - 4422. 10.1093/nar/5.11.4417. Green open access

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Abstract

The structure of a 1"2 complex of adenylyl-(3',5')-adenosine phosphate and proflavine hemisulfate has been determined using the methods of x-ray crystallography. Since the ApA does not form a mini double helix, it may serve as a model for the interaction of planar molecules with single stranded nucleic acids. The dinucleotide adopts an extended conformation with the adenines in adjacent molecules forming base pairs. A most unusual feature of the molecule is that it does not obey the "rigid nucleotide" concept although none of the torsion angles occur in energetically unfavourable regions. This is most probably due to the strong interactions between the proflavine and the oligonucleotide.

Type: Article
Title: A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded regions in RNA.
Location: ENGLAND
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/nar/5.11.4417
Publisher version: http://dx.doi.org/10.1093/nar/5.11.4417
Language: English
Additional information: PMCID: PMC342758. The Author(s)1978. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Acridines, Adenine Nucleotides, Adenosine, Crystallization, Models, Biological, Models, Molecular, Nucleic Acid Conformation, Proflavine, RNA, X-Ray Diffraction
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/1367915
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