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Studies on the conformation and dynamics of the C8-substituted guanine adduct of the carcinogen acetylaminofluorene; model for a possible Z-DNA modified structure.

Neidle, S; Kuroda, R; Broyde, S; Hingerty, BE; Levine, RA; Miller, DW; Evans, FE; (1984) Studies on the conformation and dynamics of the C8-substituted guanine adduct of the carcinogen acetylaminofluorene; model for a possible Z-DNA modified structure. Nucleic Acids Res , 12 (21) 8219 - 8233. 10.1093/nar/12.21.8219. Green open access

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Abstract

The structure of an adduct between guanine and the carcinogen acetylaminofluorene has been examined in the solid state by X-ray crystallography, and in solution by NMR techniques. The observed conformations have been compared with predictions from energy calculations and their relevance to models of adducts with DNA has been examined.

Type: Article
Title: Studies on the conformation and dynamics of the C8-substituted guanine adduct of the carcinogen acetylaminofluorene; model for a possible Z-DNA modified structure.
Location: ENGLAND
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/nar/12.21.8219
Publisher version: http://dx.doi.org/10.1093/nar/12.21.8219
Language: English
Additional information: PMCID: PMC320303. © IRL Press Limited. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: 2-Acetylaminofluorene, Chemical Phenomena, Chemistry, DNA, Guanine, Magnetic Resonance Spectroscopy, Mass Spectrometry, Models, Molecular, Molecular Conformation, Nucleic Acid Conformation, X-Ray Diffraction
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/1367913
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