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MOLECULAR-MODELLING AND BIOPHYSICAL STUDIES ON MODIFIED AND UNMODIFIED OLIGONUCLEOTIDES

GUNNING, J; CUTBUSH, S; KURODA, R; NEIDLE, S; (1984) MOLECULAR-MODELLING AND BIOPHYSICAL STUDIES ON MODIFIED AND UNMODIFIED OLIGONUCLEOTIDES. ACTA CRYSTALLOGRAPHICA SECTION A , 40 (Supple) C46 - C46. Green open access

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Abstract

Computer graphics modelling and energy calculations have been carried out on a series of modified and unmodified oligonucleotides to investigate the effects of base deletion, base substitution and base methylation, particularly 06-methylguanine and 5-methylcytosine, as well as the substitution of bases by analogues.

Type: Article
Title: MOLECULAR-MODELLING AND BIOPHYSICAL STUDIES ON MODIFIED AND UNMODIFIED OLIGONUCLEOTIDES
Open access status: An open access version is available from UCL Discovery
Publisher version: http://scripts.iucr.org/cgi-bin/paper?a48842
Language: English
Additional information: Copyright © International Union of Crystallography
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: https://discovery.ucl.ac.uk/id/eprint/1367912
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