Shieh, HS;
Berman, HM;
Dabrow, M;
Neidle, S;
(1980)
The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments.
Nucleic Acids Res
, 8
(1)
85 - 97.
10.1093/nar/8.1.85.
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Abstract
A 2:2 complex of proflavine and deoxycytidylyl-3', 5'-guanosine has been crystallized and its structure determined by x-ray crystallography. The two dinucleoside phosphate strands form self complementary duplexes with Watson Crick hydrogen bonds. One proflavin is asymmetrically intercalated between the base pairs and the other is stacked above them. The conformations of the nucleotides are unusual in that one strand has C3',C2'endomixed sugar puckering and the other has C3',C3' endo deoxyribose sugars. These results show that the conformation of the 3'sugar is of secondary importance to the intercalated geometry.
| Type: | Article |
|---|---|
| Title: | The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments. |
| Location: | ENGLAND |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/nar/8.1.85 |
| Publisher version: | http://dx.doi.org/10.1093/nar/8.1.85 |
| Language: | English |
| Additional information: | PMCID: PMC327244. © IRL Press Limited. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Acridines, DNA, Molecular Conformation, Nucleic Acid Conformation, Oligonucleotides, Proflavine, RNA, Structure-Activity Relationship, X-Ray Diffraction |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1367094 |
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