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Making co-enrolment feasible for randomised controlled trials in paediatric intensive care.

Harron, K; Lee, T; Ball, T; Mok, Q; Gamble, C; Macrae, D; Gilbert, R; (2012) Making co-enrolment feasible for randomised controlled trials in paediatric intensive care. PLOS One , 7 (8) , Article e41791. 10.1371/journal.pone.0041791. Green open access

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Abstract

Enrolling children into several trials could increase recruitment and lead to quicker delivery of optimal care in paediatric intensive care units (PICU). We evaluated decisions taken by clinicians and parents in PICU on co-enrolment for two large pragmatic trials: the CATCH trial (CATheters in CHildren) comparing impregnated with standard central venous catheters (CVCs) for reducing bloodstream infection in PICU and the CHIP trial comparing tight versus standard control of hyperglycaemia.

Type: Article
Title: Making co-enrolment feasible for randomised controlled trials in paediatric intensive care.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0041791
Publisher version: http://dx.doi.org/10.1371/journal.pone.0041791
Language: English
Additional information: © Harron et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This project was funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme (project number 08/13/47). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: Adolescent, Central Venous Catheters, Child, Child, Preschool, Decision Making, Female, Humans, Hyperglycemia, Infant, Infection Control, Intensive Care, Male, Randomized Controlled Trials as Topic
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1366627
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