Howard, R;
McShane, R;
Lindesay, J;
Ritchie, C;
Baldwin, A;
Barber, R;
Burns, A;
... Phillips, P; + view all
(2012)
Donepezil and memantine for moderate-to-severe Alzheimer's disease.
The New England Journal of Medicine
, 366
(10)
893 - 903.
10.1056/NEJMoa1106668.
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Abstract
Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer's disease. It is not known whether treatment benefits continue after the progression to moderate-to-severe disease.
| Type: | Article |
|---|---|
| Title: | Donepezil and memantine for moderate-to-severe Alzheimer's disease |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1056/NEJMoa1106668 |
| Publisher version: | http://dx.doi.org/10.1056/NEJMoa1106668 |
| Language: | English |
| Additional information: | “From New England Journal of Medicine, Robert Howard, M.D., et al., Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease, Volume No.366, Page No. 893-903 © 2012 Massachusetts Medical Society. Reprinted with permission. |
| Keywords: | Aged, Aged, 80 and over, Alzheimer disease, Cholinesterase inhibitors, Double-blind method, Drug synergism, Drug therapy, Combination, Excitatory amino acid antagonists, Female, Humans, Indans, Kaplan-meier estimate, Male, Memantine, Patient dropouts, Piperidines, Psychological Tests, Receptors, N-methyl-d-aspartate, Treatment outcome |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1366016 |
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