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Donepezil and memantine for moderate-to-severe Alzheimer's disease

Howard, R; McShane, R; Lindesay, J; Ritchie, C; Baldwin, A; Barber, R; Burns, A; ... Phillips, P; + view all (2012) Donepezil and memantine for moderate-to-severe Alzheimer's disease. The New England Journal of Medicine , 366 (10) 893 - 903. 10.1056/NEJMoa1106668. Green open access

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Abstract

Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer's disease. It is not known whether treatment benefits continue after the progression to moderate-to-severe disease.

Type: Article
Title: Donepezil and memantine for moderate-to-severe Alzheimer's disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1056/NEJMoa1106668
Publisher version: http://dx.doi.org/10.1056/NEJMoa1106668
Language: English
Additional information: “From New England Journal of Medicine, Robert Howard, M.D., et al., Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease, Volume No.366, Page No. 893-903 © 2012 Massachusetts Medical Society. Reprinted with permission.
Keywords: Aged, Aged, 80 and over, Alzheimer disease, Cholinesterase inhibitors, Double-blind method, Drug synergism, Drug therapy, Combination, Excitatory amino acid antagonists, Female, Humans, Indans, Kaplan-meier estimate, Male, Memantine, Patient dropouts, Piperidines, Psychological Tests, Receptors, N-methyl-d-aspartate, Treatment outcome
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1366016
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