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Hand weakness in Charcot-Marie-Tooth disease 1X.

Arthur-Farraj, PJ; Murphy, SM; Laura, M; Lunn, MP; Manji, H; Blake, J; Ramdharry, G; ... Reilly, MM; + view all (2012) Hand weakness in Charcot-Marie-Tooth disease 1X. Neuromuscular Disorders , 22 (7) 622 - 626. 10.1016/j.nmd.2012.02.008. Green open access

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Abstract

There have been suggestions from previous studies that patients with Charcot-Marie-Tooth disease (CMT) have weaker dominant hand muscles. Since all studies to date have included a heterogeneous group of CMT patients we decided to analyse hand strength in 43 patients with CMT1X. We recorded handedness and the MRC scores for the first dorsal interosseous and abductor pollicis brevis muscles, median and ulnar nerve compound motor action potentials and conduction velocities in dominant and non-dominant hands. Twenty-two CMT1X patients (51%) had a weaker dominant hand; none had a stronger dominant hand. Mean MRC scores were significantly higher for first dorsal interosseous and abductor pollicis brevis in non-dominant hands compared to dominant hands. Median nerve compound motor action potentials were significantly reduced in dominant compared to non-dominant hands. We conclude that the dominant hand is weaker than the non-dominant hand in patients with CMT1X.

Type: Article
Title: Hand weakness in Charcot-Marie-Tooth disease 1X.
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.nmd.2012.02.008
Publisher version: http://dx.doi.org/10.1016/j.nmd.2012.02.008
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3657175
Keywords: Adult, Charcot-Marie-Tooth Disease, Connexins, Disability Evaluation, Electromyography, Evoked Potentials, Motor, Female, Hand, Hand Strength, Humans, Male, Median Nerve, Middle Aged, Muscle Weakness, Mutation, Neural Conduction, Retrospective Studies, Sex Factors, Ulnar Nerve
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1365541
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