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Neural representations of location composed of spatially periodic bands.

Krupic, J; Burgess, N; O'Keefe, J; (2012) Neural representations of location composed of spatially periodic bands. Science , 337 (6096) 853 - 857. 10.1126/science.1222403. Green open access

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Abstract

The mammalian hippocampal formation provides neuronal representations of environmental location, but the underlying mechanisms are poorly understood. Here, we report a class of cells whose spatially periodic firing patterns are composed of plane waves (or bands) drawn from a discrete set of orientations and wavelengths. The majority of cells recorded in parasubicular and medial entorhinal cortices of freely moving rats belonged to this class and included grid cells, an important subset that corresponds to three bands at 60° orientations and has the most stable firing pattern. Occasional changes between hexagonal and nonhexagonal patterns imply a common underlying mechanism. Our results indicate a Fourier-like spatial analysis underlying neuronal representations of location, and suggest that path integration is performed by integrating displacement along a restricted set of directions.

Type: Article
Title: Neural representations of location composed of spatially periodic bands.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.1222403
Publisher version: http://dx.doi.org/10.1126/science.1222403
Language: English
Additional information: This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Vol 37, (2012), doi: 10.1126/science.1222403
Keywords: Animals, Entorhinal Cortex, Fourier Analysis, Hippocampus, Male, Neurons, Rats
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/1365481
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