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Meta-analysis of sex difference in testosterone levels in umbilical cord blood

Barry, JA; Hardiman, PJ; Siddiqui, MR; Thomas, M; (2011) Meta-analysis of sex difference in testosterone levels in umbilical cord blood. Journal of Obstetrics and Gynaecology , 31 (8) pp. 697-702. 10.3109/01443615.2011.614971. Green open access

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Abstract

This meta-analysis reviewed published literature comparing human male and female umbilical cord total testosterone (T) levels. A total of 18 studies using 1,229 samples from 602 male and 627 female newborns were analysed using the RevMan 5 statistical package. Analysis using the inverse variance method based on a random-effects model revealed significantly higher cord T in boys than girls at a moderate effect size (Hedges' g = 0.57). There was significant heterogeneity between the 18 studies, although the five studies using direct assays showed no heterogeneity. For studies using extraction and chromatography, those that combined T from arterial and venous cord blood found a larger sex difference than those using only cord venous samples (Hedges' g = 0.94 vs 0.32); this suggests umbilical cord venous T is of maternal/placental origin and arterial T is of fetal origin. The wide range of T values between studies suggests high cross-reactivity in the assay methods reviewed.

Type: Article
Title: Meta-analysis of sex difference in testosterone levels in umbilical cord blood
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.3109/01443615.2011.614971
Publisher version: http://dx.doi.org/10.3109/01443615.2011.614971
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Female, Fetal Blood, Humans, Infant, Newborn, Male, Placenta, Polycystic Ovary Syndrome, Pregnancy, Sex Characteristics, Testosterone, Umbilical Arteries, Umbilical Veins
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Reproductive Health
URI: https://discovery.ucl.ac.uk/id/eprint/1364665
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