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An unexpected sequence of events: mismatch detection in the human hippocampus

Kumaran, D; Maguire, EA; (2006) An unexpected sequence of events: mismatch detection in the human hippocampus. PLoS Biology , 4 (12) , Article e424. 10.1371/journal.pbio.0040424. Green open access

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Abstract

The ability to identify and react to novelty within the environment is fundamental to survival. Computational models emphasize the potential role of the hippocampus in novelty detection, its unique anatomical circuitry making it ideally suited to act as a comparator between past and present experience. The hippocampus, therefore, is viewed to detect associative mismatches between what is expected based on retrieval of past experience and current sensory input. However, direct evidence that the human hippocampus performs such operations is lacking. We explored brain responses to novel sequences of objects using functional magnetic resonance imaging (fMRI), while subjects performed an incidental target detection task. Our results demonstrate that hippocampal activation was maximal when prior predictions concerning which object would appear next in a sequence were violated by sensory reality. In so doing, we establish the biological reality of associative match-mismatch computations within the human hippocampus, a process widely held to play a cardinal role in novelty detection. Our results also suggest that the hippocampus may generate predictions about how future events will unfold, and critically detect when these expectancies are violated, even when task demands do not require it. The present study also offers broader insights into the nature of essential computations carried out by the hippocampus, which may also underpin its unique contribution to episodic memory.

Type: Article
Title: An unexpected sequence of events: mismatch detection in the human hippocampus
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pbio.0040424
Publisher version: http://dx.doi.org/10.1371/journal.pbio.0040424
Language: English
Additional information: Copyright: © 2006 Kumaran and Maguire. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. - Notice of republication: This article was republished on July 30, 2019 to correct a figure which contained images that were not available for publication under the Creative Commons Attribution License. Fig 1 has been recreated by the authors using open source images. The figure legend for Fig 1 has been updated to reflect this change. References to this figure in the Materials and Methods now state that Fig 1 is visually similar to the images used in the experiments, but not identical.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science > CoMPLEX: Mat&Phys in Life Sci and Exp Bio
URI: https://discovery.ucl.ac.uk/id/eprint/136384
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