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External Clinical Validation of Prone and Supine CT Colonography Registration

Roth, H; Boone, D; Halligan, S; Hampshire, T; McClelland, J; Hu, M; Punwani, S; ... Hawkes, D; + view all (2012) External Clinical Validation of Prone and Supine CT Colonography Registration. In: Yoshida, H and Hawkes, D and Vannier, M, (eds.) Abdominal Imaging. Computational and Clinical Applications: 4th InternationalWorkshop Held in Conjunction with MICCAI 2012 Nice, France, October 1, 2012 Proceedings. (pp. 10-19). Springer Verlag: Berlin / Heidelberg, Germany. Green open access

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Abstract

This paper provides an external validation of a prone-supine registration algorithm for CT colonography (CTC). A validation sample of 49 patient cases with 66 polyps (6 to 30 mm) was selected from a publicly available, anonymized CTC archive. To enhance generalizability, no case was excluded due to poor preparation or inadequate distension. Corresponding prone and supine polyp coordinates were recorded and the endoluminal surfaces registered: a Markov Random Field technique was used to find feature matches between prone/supine acquisitions and following mapping of the endoluminal surface to a cylinder, dense surface correspondence was achieved via cylindrical non-rigid registration. The polyp registration error was determined and a subjective assessment of registration made for 2D slice-based and 3D endoluminal data display using a pre-specified scoring system. Results were compared to using “normalized distance along the colon centerline” (NDACC) which approximates to the method currently employed to match colonic positions using proprietary CT colonography interpretation software. Registration was possible in all 49 cases. Overall mean 3D polyp registration error was significantly smaller with 19.9 mm in comparison to 27.7 mm using NDACC (p=0.001). 82.7% of polyp matches were defined as “successful” in comparison to 37.1% using NDACC according to the pre-specified criteria. Similarly, using 2D visualization, 62.1% registrations were “successful” and only 22.7% using NDACC. Full surface-based prone-to-supine registration can successfully map the location of a polyp identified on one acquisition to the corresponding endoluminal surface in the opposing acquisition, greatly facilitating polyp matching and aiding interpretation. Our method compares favorably to using NDACC.

Type: Book chapter
Title: External Clinical Validation of Prone and Supine CT Colonography Registration
ISBN-13: 978-3-642-33611-9
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-642-33612-6_2
Publisher version: http://dx.doi.org/10.1007/978-3-642-33612-6_2
Language: English
Additional information: The final publication is available at www.springerlink.com
Keywords: Computer Science
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1363080
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