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Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases.

Mendoza-Naranjo, A; Cormie, P; Serrano, AE; Hu, R; O'Neill, S; Wang, CM; Thrasivoulou, C; ... Becker, DL; + view all (2012) Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases. PLOS One , 7 (5) , Article e37374. 10.1371/journal.pone.0037374. Green open access

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Abstract

Venous leg ulcers can be very hard to heal and represent a significant medical need with no effective therapeutic treatment currently available.

Type: Article
Title: Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0037374
Publisher version: http://dx.doi.org/10.1371/journal.pone.0037374
Language: English
Additional information: © 2012 Mendoza-Naranjo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This work was supported in part by Action Medical Research, and the Henry Smith Charity. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords: 3T3 Cells, Animals, Cadherins, Cell Adhesion, Cell Movement, Cell Proliferation, Connexin 43, Fluorescence Resonance Energy Transfer, Humans, Leg, Membrane Proteins, Mice, Phosphoproteins, Up-Regulation, Varicose Ulcer, Wound Healing, Zonula Occludens-1 Protein, rho GTP-Binding Proteins
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1362466
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