Buchanan, KA;
Blackman, AV;
Moreau, AW;
Elgar, D;
Costa, RP;
Lalanne, T;
Tudor Jones, AA;
... Sjöström, PJ; + view all
(2012)
Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits.
Neuron
, 75
(3)
451 - 466.
10.1016/j.neuron.2012.06.017.
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Abstract
Traditionally, NMDA receptors are located postsynaptically; yet, putatively presynaptic NMDA receptors (preNMDARs) have been reported. Although implicated in controlling synaptic plasticity, their function is not well understood and their expression patterns are debated. We demonstrate that, in layer 5 of developing mouse visual cortex, preNMDARs specifically control synaptic transmission at pyramidal cell inputs to other pyramidal cells and to Martinotti cells, while leaving those to basket cells unaffected. We also reveal a type of interneuron that mediates ascending inhibition. In agreement with synapse-specific expression, we find preNMDAR-mediated calcium signals in a subset of pyramidal cell terminals. A tuned network model predicts that preNMDARs specifically reroute information flow in local circuits during high-frequency firing, in particular by impacting frequency-dependent disynaptic inhibition mediated by Martinotti cells, a finding that we experimentally verify. We conclude that postsynaptic cell type determines presynaptic terminal molecular identity and that preNMDARs govern information processing in neocortical columns.
| Type: | Article |
|---|---|
| Title: | Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2012.06.017 |
| Publisher version: | http://dx.doi.org/10.1016/j.neuron.2012.06.017 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3657167 |
| Keywords: | Animals, Computer Simulation, Excitatory Postsynaptic Potentials, Mice, Mice, Transgenic, Microscopy, Confocal, Neocortex, Neural Pathways, Neuronal Plasticity, Neurons, Patch-Clamp Techniques, Presynaptic Terminals, Receptors, N-Methyl-D-Aspartate, Synaptic Transmission |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1361689 |
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