Nathani, R;
Moody, P;
Smith, MEB;
Fitzmaurice, RJ;
Caddick, S;
(2012)
Bioconjugation of Green Fluorescent Protein via an Unexpectedly Stable Cyclic Sulfonium Intermediate.
ChemBioChem
, 13
(9)
1283 - 1285.
10.1002/cbic.201200231.
![[thumbnail of Caddick1283_ftp.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/application_pdf.png) Preview |
PDF
Caddick1283_ftp.pdf Download (400kB) |
Abstract
Bioconjugation of superfolder GFP involving the formation of an unusually stable, and unprecedented, cyclic sulfonium species is described. This sulfonium can undergo smooth reaction with a range of nucleophiles to give sulfur-, selenium- and azide-modified GFP derivatives in high conversions.
| Type: | Article |
|---|---|
| Title: | Bioconjugation of Green Fluorescent Protein via an Unexpectedly Stable Cyclic Sulfonium Intermediate |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cbic.201200231 |
| Publisher version: | http://dx.doi.org/10.1002/cbic.201200231 |
| Language: | English |
| Additional information: | Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This work is made available under a Creative Commons license. |
| Keywords: | alkylation, bioconjugation, cysteine, protein modifications, sulfonium |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1361217 |
Archive Staff Only
 |
View Item |
