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IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.

Botelho, FM; Bauer, CM; Finch, D; Nikota, JK; Zavitz, CC; Kelly, A; Lambert, KN; ... Stämpfli, MR; + view all (2011) IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. PLOS One , 6 (12) , Article e28457. 10.1371/journal.pone.0028457. Green open access

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Abstract

Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood.

Type: Article
Title: IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0028457
Publisher version: http://dx.doi.org/10.1371/journal.pone.0028457
Language: English
Additional information: © 2011 Botelho et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The work described herein was funded in-part by the CIHR, Ontario's Early Research Award program (ERA), MedImmune and AstraZeneca; CMTB holds a Canadian Thoracic Society Studentship; MRS holds a Canadian Institutes for Health Research New Investigator Award. The funders (DF and AAH) participated in study design, as well as data collection and analysis.
Keywords: Animals, Biopsy, Caspase 1, Humans, Inflammation, Interleukin 1 Receptor Antagonist Protein, Interleukin-1alpha, Interleukin-1beta, Lung, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Neutrophils, Pulmonary Disease, Chronic Obstructive, Smoke, Smoking, Sputum
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1359637
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